Friday, May 14, 2010

Friday May 14, 2010


Q: One dose of intravenous Vitamin K antagonize the effects of warfarin for how many days?



Answer: One week

High dose of Vitamin K (= 10 mg) produce rapid reversal; however, overcorrection and warfarin resistance complicate therapy. The effects of warfarin on clotting factor synthesis are antagonize for 7 days by a 10-mg dose of vitamin K. Low doses (0.5-2.5 mg) reversed anticoagulation within 24 hours (taking little longer but) with less risk of overcorrection or resistance to reinstitution of therapy.

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